Enkhdolgor G., Sarantuya Ts., Bira N., Ouyntsetseg Kh. Chronophysiological parameters of upper gastrointestinal tract by ambulatory pH metry among Mongolians / Mongolian medical sciences in 2004. Ulaanbaatar, 2005, p. 119-120.

Chronophysiological parameters of upper gastrointestinal tract by ambulatory pH metry among Mongolians

G.Enkhdolgor, Ts.Sarantuya, N.Bira, Kh.Ouyntsetseg
Health Sciences University of Mongolia

This study is the first research work of the circadian rhythm of stomach secretary function and oesophageal intraluminal acidity among Mongolian relatively healthy people. These pH-metry parameters were appraised and renewed the physiological condition of the Mongolian people’s gastric and oesophageal functions. Using the pH metry indications of healthy population the comparable indication shows that, it can be used in various gastric acidity dependent pathologies considering the age and sex of people.

Goal. To study some quantitative measurement of chronophysiological parameters of upper gastrointestinal tract by ambulatory pH metry among Mongolians.

Objective. To study the daily rhythm of intraesophageal pH level, and gastric acidity and determine the clinical basis of the chronophysiological data of those organs.

Materials and methods. The pH metry tool, and Gastroscan-24 (Istok, Russia), were used in analyzing samples taken from 129 healthy people (58 are men, 71 are women, their average age was 35.5, average time of analysis was 22 hours and 10 minutes). During the investigation, these patients did their daily activities and had normal regimens.

Statistical processing was made by the method of chronobiological multidimensional data analysis.

Daily rhythms of intraluminal pH-level of oesophagus and stomach were classified by each hour and we have determined maximum, minimum and average measurement levels of pH and their daily dynamics.

Results. An average daily level of intraesophageal acidity was pH 6.0±1.6 or weak alkaline, the maximum level was in weak alkaline pH 6.5±1.5 environment and the minimum level was pH 3.5±0.9 acidity environment.

If consider 24 hours as one day time, maximum level of intraesophageal acidity turned into alkaline was at 7:00 o’clock, and minimum level turned into acidity was at 22:00 o’clock (p<0.001).

Compare with the De Meester’s indication of pathological reflux, the pathological reflux of Mongolian people was much lower. Frequency of acidity reflux is relatively less in Mongolian people, but for a longer duration.

By our observation, the healthy person’s average indication of stomach acidity daily rhythms is pH 2.9±0.7, minimum pH 2.2±0.5, and maximum pH 4.8±1.5. Decrease of stomach acidity occurs at 6:00, 7:00 o’clock, and increase of acid production at 2:00, 10:00 o’clock.

An average level of basal acid secretion of stomach was 1.5±0.2. Increase of acidity (pH<1.5 or in average pH 0.9±0.3) was observed in 62.0% (18 people) of patients, and decrease (pH>1.5 or in average pH 3.5±0.9) in 31%. The biorhythmological analysis of gastric pH-metry in fasting most of incidences is showed a hyper secretary function.

The acidity has been increasing in 44.0% of 24 hours, decreasing in 41.3%, and was stable in 14.7%. Increase of acidity lasts for 1-6 hours in average, from which 1-3 hours occurs in day time, and 4-6 hours in night time. Most of the hyposecretory condition related with a bile reflux, was commonly from 3:00 to 9:00 by 1-3 hours duration.

Conclusion. Results of oesophageal and gastric circadian rhytm of 18-59 aged healthy people could a chronophysiological parameters of Mongolian adults. Knowing the circadian rhythm of intraluminal acidity of esophagus gastric acid production is essential in comprehensive diagnostics, treatment of gastroenterology, recording of chrono-treatment.

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