Valitova E, Bordin D, Berezina O, Chebotareva M, Baymakanova G. The diagnosis of laryngopharyngeal reflux in patients with extraesophageal symptoms of GERD. United European Gastroenterology Journal. 2023. V. 11(S8). Poster Presentations. PP0120. P.600-601

Авторы: Валитова Э.Р.  / Бордин Д.С. / Березина О.И. / Чеботарева М.В. / Баймаканова Г.Э.

The diagnosis of laryngopharyngeal reflux in patients with extraesophageal symptoms of GERD

¹ A.S. Loginov Moscow Clinical Scientific Centre, Central Research Institute of Gastroenterology, Laboratory of Functional Diagnostics of Esophagus and Stomach, Moscow, Russia,
² A.S. Loginov Moscow Clinical Scientific Centre, Central Research Institute of Gastroenterology, Pancreatic, Biliary and Upper GI Tract Diseases, Moscow, Russia,
³ Moscow State University of Medicine and Dentistry, Moscow, Russia,
⁴ Tver State Medical University, Tver, Russia,
⁵ A.S. Loginov Moscow Clinical Scientific Centre, Pulmonology, Moscow, Russia


Contact E-Mail Address: dbordin@ mail.ru

Introduction: The gold standard for diagnosis of laryngeopharyngeal reflux is 24h MII-pH with localization of impedance nearby the upper esophageal sphincter.

Aims & Methods: The aim of the study was to evaluate high GER in patients with laryngeal symptoms of GERD.

Subjects and methods: 50 patients with extraesophageal manifestations of GERD underwent upper endoscopy, esophageal manometry and 24h MII-pH. Mean age 49,54 ±5,2 y.o. Females – 44%, males – 56%. We used new probes for 24h MII-pH with 2 impedance channels located above lower esophageal sphincter (LES) and 5 impedance channels located under and above upper esophageal sphincter (UES).

There were 3 types of probes according to the length of esophagus: 1st type – for the length 20-22 cm, 2nd type – 23-25 cm, 3rd type – 26-28 cm. The pH electrodes were at 5 cm above LES and 1 cm above UES. The location of LES and UES was detected by manometry.

Results: According to the results of 24h MII-pHmetry in the lower third of the pharynx, 21 patients had more than 1 reflux (LFR+ group), 29 patients had no reflux in the pharynx (LFR-). Patients with LFR+ significantly more often complained of hoarseness, slightly more often noted cough, burning in the oral cavity, dysphagia.

Patients with LFR- often complained of heartburn, regurgitation, sore throat, lump in the throat. The upper endoscopy showed that the frequency of occurrence of the erosive esophagitis was the equal in both groups, including Barrett’s esophagus.

The pathologic GER in the lower third of the esophagus was more common in patients with LFR + (71%) than in patients without LFR (24%). A positive correlation was revealed (r=0.46). The ratio of the physiological amount of GER was 24 and 59%, respectively.

Conclusion: The new probes allow simultaneous assessment of reflux in the lower third of the esophagus and pharynx. The amount of reflux in the lower third of the pharynx correlates with the amount in the lower third of the esophagus.

However, there are options when, with a normal number of them, there may be a high spread in the lower third of the esophagus.

Disclosure: Nothing to disclose.

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Иллюстрация, на которой представлены три упомянутые в данной работе импеданс-рН-зонда (кадр из видеозаписи спарринг-лекции Э.Р. Валитовой и С.В. Морозова «Возможности функциональной диагностики патологии пищевода»), добавлена при публикации на сайте GastroScan.ru.

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Другие материалы из этого выпуска UEG Journal (все сопровождаются переводами на русский язык):

• Rogers B, Hengehold T, Marchetti L, Sifrim D, Gyawali CP. The role of saliva production and esophageal motor function in post-reflux swallow induced peristaltic wave (PSPW) related esophageal acid clearance. United European Gastroenterology Journal. 2023. V. 11(S8). Poster Presentations. PP0108. P.594.


• Calabrese F, Pasta A, Giannini EG, Della Casa D, Cataudella G, Frazzoni M, Savarino EV, Penagini R, De Bortoli N, Savarino V, Marabotto E. The role of laryngoscopy in GERD patients with atypical symptoms - a multicentre study. United European Gastroenterology Journal. 2023. V. 11(S8). Poster Presentations. PP0118. P.599.


• de Bortoli N, Baiano Svizzero F, Visaggi P, Adamo G, Mariani L, Ovidi F, Stefani Donati D, Dulmin I, Venturini A, Buselli I, Scaramuzza G, Bellini M, Savarino EV. Baseline anxiety scores predict escalation to higher doses of paroxetine in patients with functional heartburn and reflux hypersensitivity. United European Gastroenterology Journal. 2023. V. 11(S8). Poster Presentations. PP0087. P. 583.

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