Fass R, Shapiro M, Dekel R, Sewell J. Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease - where next? Aliment Pharmacol Ther. 2005;22(2):79–94.

Популярно о болезнях ЖКТ Лекарства при болезнях ЖКТ Если лечение не помогает Адреса клиник

Авторы: Fass R. / Shapiro M.S.  / Dekel R. / Sewell J.L.

Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease - where next?

R. Fass, M. Shapiro, R. Dekel, J. Sewell

The Neuro-Enteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System and University of Arizona, School of Medicine, Tucson, AZ, USA

Proton-pump inhibitor failure has become a common clinical dilemma in gastrointestinal clinics and has been increasingly encountered at the primary care level as well. Underlying mechanisms are diverse and may overlap. Most patients who have proton-pump inhibitor failure are likely to originate from the non-erosive reflux disease phenotype. Currently, available diagnostic modalities provide limited clues to the exact underlying cause. Treatment relies primarily on escalating dosing of proton-pump inhibitors. However, new insights into the pathophysiology of proton-pump inhibitor failure are likely to provide alternative therapeutic options.

Figure. A 24-h oesophageal pH tracing in a patient who continued to be symptomatic on proton-pump inhibitor twice a day. The pH test was unrevealing despite repeated reports of heartburn symptoms by the patient implying that symptoms were probably not caused by acid reflux.

Скачать полный текст статьи (pdf, 1,58 Mb)

Классика зарубежной гастроэнтерологии

Рекомендуем также подборки представляющих для врачей-гастроэнтерологов интерес публикаций последних лет с аннотациями на русском языке:

Назад в раздел
Популярно о болезнях ЖКТ читайте в разделе "Пациентам"
Адреса клиник
Видео. Плейлисты: "Для врачей", "Для врачей-педиатров",
"Для студентов медВУЗов", "Популярная гастроэнтерология" и др.


Логотип Исток-Системы

Информация на сайте www.gastroscan.ru предназначена для образовательных и научных целей. Условия использования.