Storonova O, Paraskevova A, Trukhmanov A, Ivashkin V. Identification of lower esophageal sphincter for gastro-esophageal reflux monitoring: to compare the method of esophageal manometry and the step-up method with use of basal impedance. NGM. V.33-S2.P.39

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Авторы: Сторонова О.А. / Параскевова А.В. / Трухманов А.С. / Ивашкин В.Т.


Identification of lower esophageal sphincter for gastro-esophageal reflux monitoring: to compare the method of esophageal manometry and the step-up method with use of basal impedance

O. Storonova; A. Paraskevova; A. Trukhmanov; V. Ivashkin


I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation

См. русскоязычный вариант


Objective: Esophageal manometry and radiological diagnosis are methods for accurate positioning of multichannel intraluminal impedance pH (MII-pH) monitoring. Esophageal manometry is the gold standard for accurate to locate the lower esophageal sphincter (LES). The basal impedance step-up method is the perspective method for accurate the LES location. Our aim was to compare the method of esophageal manometry and the basal impedance step-up method for the LES location for pH impedance probe positioning in gastroesophageal reflux disease (GERD) patients.

Methods: The study included 30 GERD patients: mean age was 43.7. 24-hour MII-pH-monitoring on the JSC RPE «Istok-Sistema». Patients with gastric baseline impedance < 500 Ω were excluded. Passage in the stomach was confirmed by a stable low impedance value (i.e. < 688 Ω). The probe was withdrawn gradually 1 cm every 15 seconds up to 5 cm above the step-up impedance point. Entry into the esophagus was deemed to have occurred when a sharp and stable impedance rise was seen, defined as an increase of > 50% with respect to gastric baseline. Esophageal high-resolution manometry (HRM) was used to control place of pH-impedance probe (Solar GI Laborie/MMS, The Netherlands). The statistical analysis was done using SPSS Statistics 17.0 (the Bland-Altman comparison method, Student’s distribution, Wilcoxon signed-rank test and a linear regression model).

Results: The equation of linear regression didn’t determine the differences between the impedance step-up and the method of esophageal manometry for accurate the LES location (r² = 0.309, P < 0.001). We not found difference between two groups by the Bland-Altman comparison method (M difference = 0.28, SD difference = 0.78). When we compared them as tested with Student’s distribution and Wilcoxon's test, also no reliable differences (P = 0.52 and P = 0.051) were identified.

Conclusions: The impedance step-up method may be used for identification of the LES location for pH-impedance probe positioning in GERD patients.


Storonova O, Paraskevova A, Trukhmanov A, Ivashkin V. Identification of lower esophageal sphincter for gastro-esophageal reflux monitoring: to compare the method of esophageal manometry and the step-up method with use of basal impedance. Abstract Code: NGS15477-96. Neurogastroenterology & Motility. Volume 33, Issue S2. September 2021. P.39.



Special Issue: Abstract Supplement for NeuroGASTRO 2021 Congress, 2–4 September 2021




См. также некоторые другие публикации, связанные с конгрессом NeuroGASTRO 2021 Congress, в том числе, опубликованные в этом же выпуске Neurogastroenterology & Motility:

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