Tapete G., Di Chio T., Savarino E., et al. Which Correlation between Ocular Surface Disease And GERD? A Pilot Study // Neurogastroenterology & Motility. 2019;31(Suppl. 1):e13626.

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Авторы: Tapete G. / Di Cio T. / Savarino E.V. / Frazzoni M. / Tolone S. / Coppini F. / Zanzi F. / Bellini M. / Peroni D. / Marchi S. / de Bortoli N.


Which Correlation between Ocular Surface Disease And GERD? A Pilot Study

G. Tapete1, T. Di Chio1, E. Savarino2, M. Frazzoni3, S. Tolone4, F. Coppini1,
F. Zanzi1, M. Bellini1, D. Peroni1, S. Marchi1, N. De Bortoli1


1 University of Pisa, Italy
2 University of Padua, Italy
3 Baggiovara Hospital, Modena, Italy
4 University of Campania, Caserta, Italy

Тезисы доклада (Abstracts) на 1-м национальном конгрессе SINGEM
(Societa Italiana di Neuro-Gastro-Enterologia i Motilita), Пиза, Италия, 28.02-01.03.2019 г.

Перевод на русский: Какова корреляция между между ГЭРБ и заболеваниями поверхности глаза? Пилотное исследование


Background and Aim: Recently, ophthalmology research showed that gastroesophageal reflux maybe involved in acquired nasolacrimal duct obstruction and in some other ocular syndrome due to the fact that pepsin was recently showed in the tear of subject with GERD. The aim of this study was to evaluate the prevalence of ocular surface disease (OSD) in patients with GERD-related symptom and in healthy controls (HVs).

Materials and Methods: A group of patients with typical GERD-related symptoms were evaluated both with symptomatic questionnaire for GERD (GERDQ) and for OSD (OSDI). All patients underwent upper endoscopy and only a sub-group of patients underwent impedance and pH monitoring (MII-pH). OSDI was considered positive when > 41; GERDQ was considered positive when > 8. GERD was diagnosed if upper endoscopy showed esophageal erosion (according to LA Classification) and if MII-pH resulted positive (acid exposure time, AET > 5%; number of reflux event > 54; mean nocturnal baseline impedance, MNBI < 2292 and esophageal chemical clearance, PSPW index < 61%). We evaluated the positivity of OSDI in these sub-groups: A (erosive GERD); B (NERD with abnormal MII-pH); C (uninvestigated NERD with positive GERDQ but no MII-pH data); D (functional heartburn); E (HVs).

Results: We enrolled 100 patients (59 F) with mean age (±sd) 47.6 (11.3) yrs and 40 HVs (26 F, with mean age 37.4 ± 8.1 yrs). Upper endoscopy and GERD- monitoring test allowed to split patients in 4 groups: group A included 17 patients (7 F; 51.3 ± 7.2 yrs); group B 27 (15 F; 48.6 ± 6.2 yrs); group C 32 (21 F; 45.9 ± 16.4 yrs) and group D included 24 patients (16 F; 43.1 ± 8.5 yrs). Sixty-eight patients had a positive GERDQ. Forty-two patients had positive OSDI among patients with GERD-related symptoms and only 11/40 (27.5%) had positive OSDI ( P < 0.05). In Table 1 are detailed the results.

Conclusions: This pilot study showed that patients with GERD-related symptoms had higher recurrence of OSD-related symptoms. Detailed pathophysiological studies and a detailed ophthalmologic evaluation is needed to better define a real link between this two conditions.




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Лекарства, применяемые при заболеваниях ЖКТ
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